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Natural Progesterone for Bone and Brain Health

Progesterone is produced by ovaries and placenta in females and by adrenal glands in both sexes. Progesterone has multiple non-reproductive functions: it’s important for bone formation and strength and is synthesized by the central nervous system to perform various vital functions in the brain where it helps to regulate cognition, mood, inflammation, mitochondrial function, neurogenesis and regeneration, myelination and recovery from traumatic brain injury. Progesterone has been used clinically via different routes in several studies.  Progesterone alone or in combination with estradiol therapy may improve quality of life for a postmenopausal woman with or without a uterus. In addition to mitigating or preventing vasomotor symptoms or postmenopausal bone loss, oral progesterone causes drowsiness and can be administered at bedtime as part of an HRT regimen, and in this way can help with sleep.

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