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Baby Spitting Up? Treatment may Increase Risk of Allergies

Exposure to acid-suppressive medications or antibiotics in the first 6 months of life may increase risk of developing food allergies (especially dairy), anaphylaxis (a potentially fatal type of allergic reaction), asthma, atopic dermatitis, allergic rhinitis, allergic conjunctivitis, urticaria, contact dermatitis, medication allergy, or other allergies. A study was conducted in 792,130 children in the U.S. military health care system and published in April 2018 in JAMA Pediatrics. It followed children who had received PPIs (proton pump inhibitors) such as lansoprazole or H2 blockers such as ranitidine and found that infants given H2 blockers or PPIs were more than twice as likely to have a food allergy as those who did not receive the medications. The study concluded that acid-suppressive medications and antibiotics should not be prescribed for common conditions in babies, such as “spitting up”.

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