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Low-Dose Naltrexone for Sjogren's

Sjogren's Syndrome is a chronic autoimmune disorder that causes inflammation of the tear and salivary glands, resulting in dryness of the eyes and mouth. In addition, fatigue and musculoskeletal pain, often described as aching, is very common. Treatment directed toward alleviating the fatigue and pain associated with Sjogren's is currently very limited. Overall, LDN is well-tolerated. LDN should not be used in patients who are currently receiving opioid analgesics. Patients taking thyroid replacement may require a lower amount of thyroid medication so periodic monitoring is indicated. Ask our compounding pharmacist for more information. 


Cureus. 2019 Mar 11;11(3):e4225.

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