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Estrogen Levels and Dementia

The prevalence of Alzheimer's disease (AD) is higher for women than men, possibly influenced by sex-dependent effects of estrogen. The Cache County Study, conducted by researchers from Weill Cornell Medical College, examined the association between estrogen and cognitive decline in over 2,000 women with an average age of 75 years who were dementia-free at baseline. Higher endogenous estrogen exposure (EEE, estrogen production by the body) was associated with better cognitive status, as was duration of hormone therapy (HT). Women who initiated HT within 5 years of menopause had higher cognition scores compared with those initiating HT 6-or-more years later. HT initiated in later life may be associated with increased risks. Ask our compounding pharmacist about the benefits of customized hormone therapy.

 

References

Neurology. 2012 Oct 30;79(18):1846-52
Menopause. 2019 Oct 14. [Epub ahead of print]


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