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PPIs and Increased Risk of COVID

On July 7th, 2020, The American Journal of Gastroenterology reported that the use of PPIs appears to increase the risk of COVID-19. Proton Pump Inhibitors are commonly used to reduce stomach acid and relieve symptoms of gastric reflux. A survey of 53,130 adult Americans found that there is a dose-response relationship between the amount of acid suppression and the risk of COVID-19. Compared to those not using PPIs, those taking twice-daily PPIs had a 3.7-fold increased risk of COVID-19. In contrast, people taking less powerful drugs to suppress acid production, such as famotidine or cimetidine, were not at increased risk for COVID-19. Clinicians should consider whether twice-daily PPI dosing is necessary for individual patients, particularly those who are especially vulnerable for severe COVID-19 and if famotidine or cimetidine may be considered as an alternative treatment. 



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